Anti-infectives
(Track)
Oral candidiasis treatment: in vitro antifungal susceptibility of 148 Candida albicans isolated from oral cavity
Da Molin G
Dep. Biomedical Science and Human Oncology; Centre of Research "Population, Environment and Health"; ^PhD Anatomy and Physiology of Articulation - University of Bari, Italy
Abstract:
Introduction. The oral cavity is a primary target for some opportunistic infections such as candidiasis.
Candida adhesion and multiplication are largely regulated by the local host factors as the impairment of the oral mucosal integrity, denture wearing, poor oral hygiene. However, oral candidiasis due to drug resistant Candida species rarely appeared.
The aim of this study was to determine the antifungal susceptibility of Candida albicans isolated from oral cavity in order to confirm the literature data concerning the good performance of triazoles in the treatment of oral candidiasis.
Methods. In vitro susceptibility to fluconazole, itraconazole, posaconazole and voriconazole was performed, by E-test and Sensititre, on 148 Candida albicans isolates from oral cavity.
Results. C.albicans isolates were susceptible to all triazoles. Etest and Sensititre MIC90 values of fluconazole were 0.75 and 0.5 μg/mL, itraconazole 0.38 and 0.12 μg/mL, posaconazole 0.125 and 0.06 μg/mL, and voriconazole 0.016 and 0.008 μg/mL respectively. A good agreement between the commercial methods was shown.
Conclusions. Our data confirm the good activity of triazoles drugs against C. albicans isolated from oral cavity and highlight the need to perform antifungal susceptibility testing just in case of clinically relevant yeasts.
